Histone deacetylases – a new target for suppression of cartilage degradation?

Por Mort, John S
Publicado em 2005

Articular cartilage and changes in arthritis: Matrix degradation

Por Mort, John S, Billington, Caron J
Publicado em 2001

The role of aggrecan in normal and osteoarthritic cartilage

Por Roughley, Peter J, Mort, John S
Publicado no J Exp Orthop (2014)

Variations in aggrecan structure modulate its susceptibility to aggrecanases.

Por Roughley, Peter J, Barnett, James, Zuo, Fengrong, Mort, John S
Publicado em 2003

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Por Durigova, Michaela, Nagase, Hideaki, Mort, John S., Roughley, Peter J.
Publicado em 2010

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.

Por Sztrolovics, Robert, White, Robert J, Roughley, Peter J, Mort, John S
Publicado em 2002

Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.

Por Sztrolovics, Robert, Recklies, Anneliese D, Roughley, Peter J, Mort, John S
Publicado em 2002

Lack of Tissue Inhibitor of Metalloproteinases-3 Results in an Enhanced Inflammatory Response in Antigen-Induced Arthritis

Por Mahmoodi, Mandana, Sahebjam, Solmaz, Smookler, David, Khokha, Rama, Mort, John S.
Publicado em 2005

Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis

Por Mort, John S., Geng, Yeqing, Fisher, William D., Roughley, Peter J.
Publicado no BMC Musculoskelet Disord (2016)

S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B.

Por Krupa, Joanne C, Hasnain, Sadiq, Nägler, Dorit K, Ménard, Robert, Mort, John S
Publicado em 2002

Structural basis for the recognition and cleavage of histone H3 by cathepsin L

Por Adams-Cioaba, Melanie A., Krupa, Joanne C., Xu, Chao, Mort, John S., Min, Jinrong
Publicado em 2011

Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1

Por Ho, Yuen Yee, Baron, Murray, Recklies, Anneliese D., Roughley, Peter J., Mort, John S.
Publicado no BBA Clin (2014)

Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.

Por Conesa, Magali, Prat, Annik, Mort, John S, Marvaldi, Jacques, Lissitzky, Jean-Claude, Seidah, Nabil G
Publicado em 2003

The structure and degradation of aggrecan in human intervertebral disc

Por Roughley, Peter J., Melching, Lee I., Heathfield, Terrence F., Pearce, Richard H., Mort, John S.
Publicado em 2006

Glycosaminoglycan-Mediated Loss of Cathepsin K Collagenolytic Activity in MPS I Contributes to Osteoclast and Growth Plate Abnormalities

Por Wilson, Susan, Hashamiyan, Saadat, Clarke, Lorne, Saftig, Paul, Mort, John, Dejica, Valeria M., Brömme, Dieter
Publicado em 2009

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

Por Dejica, Valeria M, Mort, John S, Laverty, Sheila, Antoniou, John, Zukor, David J, Tanzer, Michael, Poole, A Robin
Publicado em 2012

Quantitative continuous assay for hyaluronan synthase

Por Krupa, Joanne C., Shaya, David, Chi, Lianli, Linhardt, Robert J., Cygler, Miroslaw, Withers, Stephen G., Mort, John S.
Publicado em 2006

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

Por Dejica, Valeria M., Mort, John S., Laverty, Sheila, Percival, M. David, Antoniou, John, Zukor, David J., Poole, A. Robin
Publicado em 2008

Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging

Por Akhatib, Bashar, Önnerfjord, Patrik, Gawri, Rahul, Ouellet, Jean, Jarzem, Peter, Heinegård, Dick, Mort, John, Roughley, Peter, Haglund, Lisbet
Publicado em 2013

The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases

Por Nour, Nadia, Mayer, Gaétan, Mort, John S., Salvas, Alexandre, Mbikay, Majambu, Morrison, Charlotte J., Overall, Christopher M., Seidah, Nabil G.
Publicado em 2005