Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

INTRODUCTION: The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in cartilage as determined by immunochemical assays. The distinct sites of collagen cleavage generated by collagenases and cathepsin K in...

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Detalhes bibliográficos
Main Authors: Dejica, Valeria M, Mort, John S, Laverty, Sheila, Antoniou, John, Zukor, David J, Tanzer, Michael, Poole, A Robin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446490/
https://ncbi.nlm.nih.gov/pubmed/22584047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3839
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