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Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

INTRODUCTION: The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in cartilage as determined by immunochemical assays. The distinct sites of collagen cleavage generated by collagenases and cathepsin K in...

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Autors principals: Dejica, Valeria M, Mort, John S, Laverty, Sheila, Antoniou, John, Zukor, David J, Tanzer, Michael, Poole, A Robin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446490/
https://ncbi.nlm.nih.gov/pubmed/22584047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3839
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