Transforming Growth Factor-β2 Suppresses Collagen Cleavage in Cultured Human Osteoarthritic Cartilage, Reduces Expression of Genes Associated with Chondrocyte Hypertrophy and Degradation, and Increases Prostaglandin E(2) Production

Articular cartilage degeneration in osteoarthritis (OA) involves type II collagen degradation and chondrocyte differentiation (hypertrophy). Because these changes resemble growth plate remodeling, we hypothesized that collagen degradation may be inhibitable by growth factors known to suppress growth...

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Hauptverfasser: Tchetina, Elena V., Antoniou, John, Tanzer, Michael, Zukor, David J., Poole, A. Robin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592655/
https://ncbi.nlm.nih.gov/pubmed/16400016
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