Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from ar...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Int J Rheumatol
Main Authors: Tchetina, Elena V., Markova, Galina A., Poole, A. Robin, Zukor, David J., Antoniou, John, Makarov, Sergey A., Kuzin, Aleksandr N.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155111/
https://ncbi.nlm.nih.gov/pubmed/28042296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6432867
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados