Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from ar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Rheumatol
Egile Nagusiak: Tchetina, Elena V., Markova, Galina A., Poole, A. Robin, Zukor, David J., Antoniou, John, Makarov, Sergey A., Kuzin, Aleksandr N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Hindawi Publishing Corporation 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155111/
https://ncbi.nlm.nih.gov/pubmed/28042296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6432867
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