Prostaglandin PGE(2 )at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-β2 in cultured human osteoarthritic cartilage has been shown to be associated with decreased expression of collagenases, cytokines, genes associated with chondrocyte hypertrophy, and upregulation of prostaglandin (...

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Detalhes bibliográficos
Main Authors: Tchetina, Elena V, Di Battista, John A, Zukor, David J, Antoniou, John, Poole, A Robin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206385/
https://ncbi.nlm.nih.gov/pubmed/17683641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2273
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