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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes generated by c...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Billinghurst, R C, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, H, Chen, J, Van Wart, H, Poole, A R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507973/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9119997/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119316
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