Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes generated by c...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Billinghurst, R C, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, H, Chen, J, Van Wart, H, Poole, A R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 1997
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Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507973/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9119997/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119316
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