Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes generated by c...

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Autores principales: Billinghurst, R C, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, H, Chen, J, Van Wart, H, Poole, A R
Formato: Artigo
Lenguaje:Inglês
Publicado: 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC507973/
https://ncbi.nlm.nih.gov/pubmed/9119997
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