Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

Cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular matrix of articular cartilage. In osteoarthritis (OA), the anabolic/catabolic balance of articular cartilage is disrupted with the excessive cleav...

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Detalhes bibliográficos
Main Authors: Dejica, Valeria M., Mort, John S., Laverty, Sheila, Percival, M. David, Antoniou, John, Zukor, David J., Poole, A. Robin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438294/
https://ncbi.nlm.nih.gov/pubmed/18511517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070494
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