Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.

We present a general strategy for the dominant negative reduction in the levels of type-1 membrane-bound heterodimeric proteins within the secretory pathway through fusion of the soluble ectodomain of one of the partners to the transmembrane-cytosolic tail of the lysosomal protein Lamp1. Thus, in hu...

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Bibliographic Details
Main Authors: Conesa, Magali, Prat, Annik, Mort, John S, Marvaldi, Jacques, Lissitzky, Jean-Claude, Seidah, Nabil G
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223196/
https://ncbi.nlm.nih.gov/pubmed/12444923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021301
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