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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) families. Both families of enzymes cleave aggrecan a...

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Detalhes bibliográficos
Main Authors: Durigova, Michaela, Nagase, Hideaki, Mort, John S., Roughley, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057330/
https://ncbi.nlm.nih.gov/pubmed/21055468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.10.007
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