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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) families. Both families of enzymes cleave aggrecan a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Durigova, Michaela, Nagase, Hideaki, Mort, John S., Roughley, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057330/
https://ncbi.nlm.nih.gov/pubmed/21055468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.10.007
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