Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Aggrecanases are now believed to be the principal proteinases responsible for aggrecan degradation in osteoarthritis. Given their potential as a drug target, we solved crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhibitor and...

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Bibliographische Detailangaben
Hauptverfasser: Mosyak, Lidia, Georgiadis, Katy, Shane, Tania, Svenson, Kristine, Hebert, Tracy, McDonagh, Thomas, Mackie, Stewart, Olland, Stephane, Lin, Laura, Zhong, Xiaotian, Kriz, Ronald, Reifenberg, Erica L., Collins-Racie, Lisa A., Corcoran, Christopher, Freeman, Bethany, Zollner, Richard, Marvell, Tod, Vera, Matthew, Sum, Phaik-Eng, Lavallie, Edward R., Stahl, Mark, Somers, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2008
Schlagworte:
Accelerated Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144589/
https://ncbi.nlm.nih.gov/pubmed/18042673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073287008
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