Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Aggrecanases are now believed to be the principal proteinases responsible for aggrecan degradation in osteoarthritis. Given their potential as a drug target, we solved crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhibitor and...

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Detalhes bibliográficos
Main Authors: Mosyak, Lidia, Georgiadis, Katy, Shane, Tania, Svenson, Kristine, Hebert, Tracy, McDonagh, Thomas, Mackie, Stewart, Olland, Stephane, Lin, Laura, Zhong, Xiaotian, Kriz, Ronald, Reifenberg, Erica L., Collins-Racie, Lisa A., Corcoran, Christopher, Freeman, Bethany, Zollner, Richard, Marvell, Tod, Vera, Matthew, Sum, Phaik-Eng, Lavallie, Edward R., Stahl, Mark, Somers, William
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Accelerated Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144589/
https://ncbi.nlm.nih.gov/pubmed/18042673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073287008
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