Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Aggrecanases are now believed to be the principal proteinases responsible for aggrecan degradation in osteoarthritis. Given their potential as a drug target, we solved crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhibitor and...

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Hlavní autoři: Mosyak, Lidia, Georgiadis, Katy, Shane, Tania, Svenson, Kristine, Hebert, Tracy, McDonagh, Thomas, Mackie, Stewart, Olland, Stephane, Lin, Laura, Zhong, Xiaotian, Kriz, Ronald, Reifenberg, Erica L., Collins-Racie, Lisa A., Corcoran, Christopher, Freeman, Bethany, Zollner, Richard, Marvell, Tod, Vera, Matthew, Sum, Phaik-Eng, Lavallie, Edward R., Stahl, Mark, Somers, William
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2008
Témata:
Accelerated Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144589/
https://ncbi.nlm.nih.gov/pubmed/18042673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073287008
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