Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

Por Shao, Esther S., Lin, Laura, Yao, Yucheng, Boström, Kristina I.
Publicado em 2009

Crystal Structure of a Human IκB Kinase β Asymmetric Dimer

Por Liu, Shenping, Misquitta, Yohann R., Olland, Andrea, Johnson, Mark A., Kelleher, Kerry S., Kriz, Ron, Lin, Laura L., Stahl, Mark, Mosyak, Lidia
Publicado em 2013

Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency

Por Chen, Long, Cohen, Justin, Song, Xiaoda, Zhao, Aishan, Ye, Zi, Feulner, Christine J., Doonan, Patrick, Somers, Will, Lin, Laura, Chen, Peng R.
Publicado no Sci Rep (2016)

Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics

Por Ishino, Tetsuya, Wang, Mengmeng, Mosyak, Lidia, Tam, Amy, Duan, Weili, Svenson, Kristine, Joyce, Alison, O'Hara, Denise M., Lin, Laura, Somers, William S., Kriz, Ronald
Publicado em 2013

A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv)

Por Tu, Chao, Terraube, Virginie, Tam, Amy Sze Pui, Stochaj, Wayne, Fennell, Brian J., Lin, Laura, Stahl, Mark, LaVallie, Edward R., Somers, Will, Finlay, William J. J., Mosyak, Lydia, Bard, Joel, Cunningham, Orla
Publicado no J Biol Chem (2016)

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

Por Olland, Andrea M, Strand, James, Presman, Eleonora, Czerwinski, Robert, Joseph-McCarthy, Diane, Krykbaev, Rustem, Schlingmann, Gerhard, Chopra, Rajiv, Lin, Laura, Fleming, Margaret, Kriz, Ron, Stahl, Mark, Somers, William, Fitz, Lori, Mosyak, Lidia
Publicado em 2009

Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions

Por Zhong, Xiaotian, Kieras, Elizabeth, Sousa, Eric, D'Antona, Aaron, Baber, J. Christian, He, Tao, Desharnais, Joel, Wood, Lauren, Luxenberg, Deborah, Stahl, Mark, Kriz, Ronald, Lin, Laura, Somers, Will, Fitz, Lori J., Wright, Jill F.
Publicado em 2013

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Por Mosyak, Lidia, Georgiadis, Katy, Shane, Tania, Svenson, Kristine, Hebert, Tracy, McDonagh, Thomas, Mackie, Stewart, Olland, Stephane, Lin, Laura, Zhong, Xiaotian, Kriz, Ronald, Reifenberg, Erica L., Collins-Racie, Lisa A., Corcoran, Christopher, Freeman, Bethany, Zollner, Richard, Marvell, Tod, Vera, Matthew, Sum, Phaik-Eng, Lavallie, Edward R., Stahl, Mark, Somers, William
Publicado em 2008

CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

Por Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla
Publicado em 2013