Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions

Protein biosynthesis and extracellular secretion are essential biological processes for therapeutic protein production in mammalian cells, which offer the capacity for correct folding and proper post-translational modifications. In this study, we have generated bispecific therapeutic fusion proteins...

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Detalhes bibliográficos
Main Authors: Zhong, Xiaotian, Kieras, Elizabeth, Sousa, Eric, D'Antona, Aaron, Baber, J. Christian, He, Tao, Desharnais, Joel, Wood, Lauren, Luxenberg, Deborah, Stahl, Mark, Kriz, Ronald, Lin, Laura, Somers, Will, Fitz, Lori J., Wright, Jill F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543023/
https://ncbi.nlm.nih.gov/pubmed/23184956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.417717
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