Cathepsin K inhibitors for osteoporosis and potential off-target effects

Por Brömme, Dieter, Lecaille, Fabien
Publicado em 2009

Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses

Por Wilson, Susan, Brömme, Dieter
Publicado em 2010

The role of basic amino acid surface clusters on the collagenase activity of cathepsin K

Por Nallaseth, Ferez S., Lecaille, Fabien, Li, Zhenqiang, Brömme, Dieter
Publicado no Biochemistry (2013)

Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption

Por Wilson, Susan R., Peters, Christoph, Saftig, Paul, Brömme, Dieter
Publicado em 2009

ApoE-Deficient Mice on Cholate-Containing High-Fat Diet Reveal a Pathology Similar to Lung Sarcoidosis

Por Samokhin, Andriy O., Bühling, Frank, Theissig, Franz, Brömme, Dieter
Publicado em 2010

The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

Por Saftig Paul, Weber Ekkehard, Leung Nelson, Zhang Dongwei, Brömme Dieter
Publicado em 2011-05-01

The S2 subsites of cathepsins K and L and their contribution to collagen degradation

Por Lecaille, Fabien, Chowdhury, Shafinaz, Purisima, Enrico, Brömme, Dieter, Lalmanach, Gilles
Publicado em 2007

The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

Por Zhang, Dongwei, Leung, Nelson, Weber, Ekkehard, Saftig, Paul, Brömme, Dieter
Publicado em 2011

Probing cathepsin K activity with a selective substrate spanning its active site.

Por Lecaille, Fabien, Weidauer, Enrico, Juliano, Maria A, Brömme, Dieter, Lalmanach, Gilles
Publicado em 2003

Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis

Por Samokhin, Andriy O, Gauthier, Jacques Yves, Percival, M David, Brömme, Dieter
Publicado em 2011

A Putative Role for Cathepsin K in Degradation of AA and AL Amyloidosis

Por Röcken, Christoph, Stix, Barbara, Brömme, Dieter, Ansorge, Siegfried, Roessner, Albert, Bühling, Frank
Publicado em 2001

Elastin Degradation by Cathepsin V Requires Two Exosites

Por Du, Xin, Chen, Nelson L. H., Wong, Andre, Craik, Charles S., Brömme, Dieter
Publicado em 2013

Effects of Cysteine Proteases on the Structural and Mechanical Properties of Collagen Fibers

Por Panwar, Preety, Du, Xin, Sharma, Vidhu, Lamour, Guillaume, Castro, Mickael, Li, Hongbin, Brömme, Dieter
Publicado em 2013

Structural basis of collagen fiber degradation by cathepsin K

Por Aguda, Adeleke H., Panwar, Preety, Du, Xin, Nguyen, Nham T., Brayer, Gary D., Brömme, Dieter
Publicado no Proc Natl Acad Sci U S A (2014)

The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition

Por Schick, Charles, Brömme, Dieter, Bartuski, Allison J., Uemura, Yoshiki, Schechter, Norman M., Silverman, Gary A.
Publicado em 1998

Glycosaminoglycan-Mediated Loss of Cathepsin K Collagenolytic Activity in MPS I Contributes to Osteoclast and Growth Plate Abnormalities

Por Wilson, Susan, Hashamiyan, Saadat, Clarke, Lorne, Saftig, Paul, Mort, John, Dejica, Valeria M., Brömme, Dieter
Publicado em 2009

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

Por Zhang, Dongwei, Huang, Chuangfang, Yang, Changfu, Liu, Renzuo J, Wang, Jifeng, Niu, Jianzhao, Brömme, Dieter
Publicado em 2011

Pivotal Role of Cathepsin K in Lung Fibrosis

Por Bühling, Frank, Röcken, Christoph, Brasch, Frank, Hartig, Roland, Yasuda, Yoshiyuki, Saftig, Paul, Brömme, Dieter, Welte, Tobias
Publicado em 2004

Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications

Por Panwar, Preety, Lamour, Guillaume, Mackenzie, Neil C. W., Yang, Heejae, Ko, Frank, Li, Hongbin, Brömme, Dieter
Publicado no J Biol Chem (2015)

A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

Por Panwar, Preety, Søe, Kent, Guido, Rafael VC, Bueno, Renata V C, Delaisse, Jean‐Marie, Brömme, Dieter
Publicado no Br J Pharmacol (2016)