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A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K
BACKGROUND AND PURPOSE: Cathepsin K (CatK) is a major drug target for the treatment of osteoporosis. Potent active site‐directed inhibitors have been developed and showed variable success in clinical trials. These inhibitors block the entire activity of CatK and thus may interfere with other pathway...
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| Publié dans: | Br J Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341232/ https://ncbi.nlm.nih.gov/pubmed/26562357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13383 |
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