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A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K
BACKGROUND AND PURPOSE: Cathepsin K (CatK) is a major drug target for the treatment of osteoporosis. Potent active site‐directed inhibitors have been developed and showed variable success in clinical trials. These inhibitors block the entire activity of CatK and thus may interfere with other pathway...
में बचाया:
| में प्रकाशित: | Br J Pharmacol |
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| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley and Sons Inc.
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341232/ https://ncbi.nlm.nih.gov/pubmed/26562357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13383 |
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