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Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification

Elastin plays an important role in maintaining blood vessel integrity. Proteolytic degradation of elastin in the vascular system promotes the development of atherosclerosis, including blood vessel calcification. Cysteine cathepsins have been implicated in this process, however, their role in disease...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Andrault, Pierre-Marie, Panwar, Preety, Mackenzie, Neil C. W., Brömme, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609650/
https://ncbi.nlm.nih.gov/pubmed/31273243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45918-1
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