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Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification

Elastin plays an important role in maintaining blood vessel integrity. Proteolytic degradation of elastin in the vascular system promotes the development of atherosclerosis, including blood vessel calcification. Cysteine cathepsins have been implicated in this process, however, their role in disease...

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Pubblicato in:Sci Rep
Autori principali: Andrault, Pierre-Marie, Panwar, Preety, Mackenzie, Neil C. W., Brömme, Dieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609650/
https://ncbi.nlm.nih.gov/pubmed/31273243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45918-1
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