Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone

BACKGROUND AND PURPOSE: Attempts to generate active site‐directed cathepsin K (CatK) inhibitors for the treatment of osteoporosis have failed because of side effects. We have previously shown that an ectosteric tanshinone CatK inhibitor isolated from Salvia miltiorrhiza blocked, selectively, the col...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Panwar, Preety, Law, Simon, Jamroz, Andrew, Azizi, Pouya, Zhang, Dongwei, Ciufolini, Marco, Brömme, Dieter
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825304/
https://ncbi.nlm.nih.gov/pubmed/29278432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14133
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