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A novel approach to inhibit bone resorption: exosite inhibitors against cathepsin K

BACKGROUND AND PURPOSE: Cathepsin K (CatK) is a major drug target for the treatment of osteoporosis. Potent active site‐directed inhibitors have been developed and showed variable success in clinical trials. These inhibitors block the entire activity of CatK and thus may interfere with other pathway...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Panwar, Preety, Søe, Kent, Guido, Rafael VC, Bueno, Renata V C, Delaisse, Jean‐Marie, Brömme, Dieter
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341232/
https://ncbi.nlm.nih.gov/pubmed/26562357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13383
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