The effect of cathepsin K deficiency on airway development and TGF-β1 degradation

BACKGROUND: Cathepsin K, a cysteine protease predominantly expressed in osteoclasts, is a major drug target for the treatment of osteoporosis. Recent findings, however, indicate that cathepsin K is also involved in non-skeletal metabolism. The development of fibrotic phenotypes in lung and skin is a...

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Autores principales: Zhang, Dongwei, Leung, Nelson, Weber, Ekkehard, Saftig, Paul, Brömme, Dieter
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125223/
https://ncbi.nlm.nih.gov/pubmed/21627832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-72
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