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Cathepsin K inhibitors for osteoporosis and potential off-target effects
Cathepsin K is a highly potent collagenase and the predominant papain-like cysteine protease expressed in osteoclasts. Cathepsin K deficiencies in humans and mice have underlined the central role of this protease in bone resorption and thus rendered the enzyme an attractive target for anti-resorptiv...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3110777/ https://ncbi.nlm.nih.gov/pubmed/19388876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543780902832661 |
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