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Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned

Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also found in a variety of other tissues. Secretion of cathepsin K from the osteoclast into the sealed osteoclast–bone cell i...

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Библиографические подробности
Опубликовано в: :Endocr Rev
Главные авторы: Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, Khosla, Sundeep
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546879/
https://ncbi.nlm.nih.gov/pubmed/28651365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2015-1114
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