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Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis

Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme responsible for the degradation of bone collagen. Odanacatib is a selective, reversible inhibitor of CatK at subnanomolar p...

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Bibliografski detalji
Izdano u:Br J Clin Pharmacol
Glavni autori: Stone, Julie A., McCrea, Jacqueline B., Witter, Rose, Zajic, Stefan, Stoch, S. Aubrey
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533439/
https://ncbi.nlm.nih.gov/pubmed/30663085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13869
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