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Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis

Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme responsible for the degradation of bone collagen. Odanacatib is a selective, reversible inhibitor of CatK at subnanomolar p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Clin Pharmacol
Egile Nagusiak: Stone, Julie A., McCrea, Jacqueline B., Witter, Rose, Zajic, Stefan, Stoch, S. Aubrey
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533439/
https://ncbi.nlm.nih.gov/pubmed/30663085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13869
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