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Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis
Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme responsible for the degradation of bone collagen. Odanacatib is a selective, reversible inhibitor of CatK at subnanomolar p...
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| Pubblicato in: | Br J Clin Pharmacol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533439/ https://ncbi.nlm.nih.gov/pubmed/30663085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13869 |
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