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Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis
Cathepsin K (CatK) is a cysteine protease abundantly expressed by osteoclasts and localized in the lysosomes and resorption lacunae of these cells. CatK is the principal enzyme responsible for the degradation of bone collagen. Odanacatib is a selective, reversible inhibitor of CatK at subnanomolar p...
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| Publié dans: | Br J Clin Pharmacol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6533439/ https://ncbi.nlm.nih.gov/pubmed/30663085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13869 |
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