Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation: EVIDENCE FOR AN INTRACELLULAR ROUTE

Elevated levels of plasma low density lipoprotein (LDL)-cholesterol, leading to familial hypercholesterolemia, are enhanced by mutations in at least three major genes, the LDL receptor (LDLR), its ligand apolipoprotein B, and the proprotein convertase PCSK9. Single point mutations in PCSK9 are assoc...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Poirier, Steve, Mayer, Gaetan, Poupon, Viviane, McPherson, Peter S., Desjardins, Roxane, Ly, Kevin, Asselin, Marie-Claude, Day, Robert, Duclos, Franck J., Witmer, Mark, Parker, Rex, Prat, Annik, Seidah, Nabil G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2009
विषय:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781431/
https://ncbi.nlm.nih.gov/pubmed/19635789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037085
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