Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat met...

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Dettagli Bibliografici
Autori principali: Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782032/
https://ncbi.nlm.nih.gov/pubmed/19535340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014928
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