Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes1,2. SIRT1, an NAD(+)-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeos...

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Main Authors: Milne, Jill C., Lambert, Philip D., Schenk, Simon, Carney, David P., Smith, Jesse J., Gagne, David J., Jin, Lei, Boss, Olivier, Perni, Robert B., Vu, Chi B., Bemis, Jean E., Xie, Roger, Disch, Jeremy S., Ng, Pui Yee, Nunes, Joseph J., Lynch, Amy V., Yang, Hongying, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Iffland, Andre, Lavu, Siva, Medvedik, Oliver, Sinclair, David A., Olefsky, Jerrold M., Jirousek, Michael R., Elliott, Peter J., Westphal, Christoph H.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753457/
https://ncbi.nlm.nih.gov/pubmed/18046409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06261
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