Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors

Por Tsai, Alice W., McNeil, Colleen F., Leeman, Joshua R., Bennett, Hamilton B., Nti-Addae, Kwame, Huang, Cassey, Germann, Ursula A., Byrn, Randal A., Berlioz-Seux, Francoise, Rijnbrand, Rene, Clark, Michael P., Charifson, Paul S., Jones, Steven M.
Publicado no Antimicrob Agents Chemother (2015)

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

Por Byrn, Randal A., Jones, Steven M., Bennett, Hamilton B., Bral, Chris, Clark, Michael P., Jacobs, Marc D., Kwong, Ann D., Ledeboer, Mark W., Leeman, Joshua R., McNeil, Colleen F., Murcko, Mark A., Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W., Zhou, Yi, Charifson, Paul S.
Publicado no Antimicrob Agents Chemother (2015)

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

Por Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Por Perni, Robert B., Almquist, Susan J., Byrn, Randal A., Chandorkar, Gurudatt, Chaturvedi, Pravin R., Courtney, Lawrence F., Decker, Caroline J., Dinehart, Kirk, Gates, Cynthia A., Harbeson, Scott L., Heiser, Angela, Kalkeri, Gururaj, Kolaczkowski, Elaine, Lin, Kai, Luong, Yu-Ping, Rao, B. Govinda, Taylor, William P., Thomson, John A., Tung, Roger D., Wei, Yunyi, Kwong, Ann D., Lin, Chao
Publicado em 2006

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2

Por Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)