A Novel Inhibitor of Gyrase B Is a Potent Drug Candidate for Treatment of Tuberculosis and Nontuberculosis Mycobacterial Infections

Por Locher, Christopher P., Jones, Steven M., Hanzelka, Brian L., Perola, Emanuele, Shoen, Carolyn M., Cynamon, Michael H., Ngwane, Andile H., Wiid, Ian J., van Helden, Paul D., Betoudji, Fabrice, Nuermberger, Eric L., Thomson, John A.
Publicado no Antimicrob Agents Chemother (2015)

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Por VanderVen, Brian C., Fahey, Ruth J., Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B., Memmott, Christine, Crowe, Adam M., Eltis, Lindsay D., Perola, Emanuele, Deininger, David D., Wang, Tiansheng, Locher, Christopher P., Russell, David G.
Publicado no PLoS Pathog (2015)

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

Por Byrn, Randal A., Jones, Steven M., Bennett, Hamilton B., Bral, Chris, Clark, Michael P., Jacobs, Marc D., Kwong, Ann D., Ledeboer, Mark W., Leeman, Joshua R., McNeil, Colleen F., Murcko, Mark A., Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W., Zhou, Yi, Charifson, Paul S.
Publicado no Antimicrob Agents Chemother (2015)

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

Por Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2

Por Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)