Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we identified a significant number of novel compounds...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS Pathog
Main Authors: VanderVen, Brian C., Fahey, Ruth J., Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B., Memmott, Christine, Crowe, Adam M., Eltis, Lindsay D., Perola, Emanuele, Deininger, David D., Wang, Tiansheng, Locher, Christopher P., Russell, David G.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2015
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335503/
https://ncbi.nlm.nih.gov/pubmed/25675247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004679
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