A Novel Inhibitor of Gyrase B Is a Potent Drug Candidate for Treatment of Tuberculosis and Nontuberculosis Mycobacterial Infections

New drugs to treat drug-resistant tuberculosis are urgently needed. Extensively drug-resistant and probably the totally drug-resistant tuberculosis strains are resistant to fluoroquinolones like moxifloxacin, which target gyrase A, and most people infected with these strains die within a year. In th...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Locher, Christopher P., Jones, Steven M., Hanzelka, Brian L., Perola, Emanuele, Shoen, Carolyn M., Cynamon, Michael H., Ngwane, Andile H., Wiid, Ian J., van Helden, Paul D., Betoudji, Fabrice, Nuermberger, Eric L., Thomson, John A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325822/
https://ncbi.nlm.nih.gov/pubmed/25534737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04347-14
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