Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

[Image: see text] JNJ-63623872 (2) is a first-in-class, orally bioavailable compound that offers significant potential for the treatment of pandemic and seasonal influenza. Early lead optimization efforts in our 7-azaindole series focused on 1,3-diaminocyclohexyl amide and urea substitutions on the...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2017
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304303/
https://ncbi.nlm.nih.gov/pubmed/28197323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00487
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