Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV a...

Por Bellon, Steven, Parsons, Jonathan D., Wei, Yunyi, Hayakawa, Koto, Swenson, Lora L., Charifson, Paul S., Lippke, Judith A., Aldape, Robert, Gross, Christian H.
Publicado em 2004

In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class

Por Mani, Nagraj, Gross, Christian H., Parsons, Jonathan D., Hanzelka, Brian, Müh, Ute, Mullin, Steve, Liao, Yusheng, Grillot, Anne-Laure, Stamos, Dean, Charifson, Paul S., Grossman, Trudy H.
Publicado em 2006

Active-Site Residues of Escherichia coli DNA Gyrase Required in Coupling ATP Hydrolysis to DNA Supercoiling and Amino Acid Substitutions Leading to Novobiocin Resistance

Por Gross, Christian H., Parsons, Jonathan D., Grossman, Trudy H., Charifson, Paul S., Bellon, Steven, Jernee, James, Dwyer, Maureen, Chambers, Stephen P., Markland, William, Botfield, Martyn, Raybuck, Scott A.
Publicado em 2003

Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds

Por Grossman, Trudy H., Bartels, Douglas J., Mullin, Steve, Gross, Christian H., Parsons, Jonathan D., Liao, Yusheng, Grillot, Anne-Laure, Stamos, Dean, Olson, Eric R., Charifson, Paul S., Mani, Nagraj
Publicado em 2007

Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors

Por Tsai, Alice W., McNeil, Colleen F., Leeman, Joshua R., Bennett, Hamilton B., Nti-Addae, Kwame, Huang, Cassey, Germann, Ursula A., Byrn, Randal A., Berlioz-Seux, Francoise, Rijnbrand, Rene, Clark, Michael P., Charifson, Paul S., Jones, Steven M.
Publicado no Antimicrob Agents Chemother (2015)

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

Por Byrn, Randal A., Jones, Steven M., Bennett, Hamilton B., Bral, Chris, Clark, Michael P., Jacobs, Marc D., Kwong, Ann D., Ledeboer, Mark W., Leeman, Joshua R., McNeil, Colleen F., Murcko, Mark A., Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W., Zhou, Yi, Charifson, Paul S.
Publicado no Antimicrob Agents Chemother (2015)

Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV

Por O’Dowd, Hardwin, Shannon, Dean E., Chandupatla, Kishan R., Dixit, Vaishali, Engtrakul, Juntyma J., Ye, Zhengqi, Jones, Steven M., O’Brien, Colleen F., Nicolau, David P., Tessier, Pamela R., Crandon, Jared L., Song, Bin, Macikenas, Dainius, Hanzelka, Brian L., Le Tiran, Arnaud, Bennani, Youssef L., Charifson, Paul S., Grillot, Anne-Laure
Publicado no ACS Med Chem Lett (2015)

Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza

Por Bandarage, Upul K., Clark, Michael P., Perola, Emanuele, Gao, Huai, Jacobs, Marc D., Tsai, Alice, Gillespie, Jeffery, Kennedy, Joseph M., Maltais, François, Ledeboer, Mark W., Davies, Ioana, Gu, Wenxin, Byrn, Randal A., Nti Addae, Kwame, Bennett, Hamilton, Leeman, Joshua R., Jones, Steven M., O’Brien, Colleen, Memmott, Christine, Bennani, Youssef, Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2

Por Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Publicado no ACS Med Chem Lett (2017)