Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase

Topoisomerase IV and DNA gyrase are related bacterial type II topoisomerases that utilize the free energy from ATP hydrolysis to catalyze topological changes in the bacterial genome. The essential function of DNA gyrase is the introduction of negative DNA supercoils into the genome, whereas the esse...

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Autores principales: Bellon, Steven, Parsons, Jonathan D., Wei, Yunyi, Hayakawa, Koto, Swenson, Lora L., Charifson, Paul S., Lippke, Judith A., Aldape, Robert, Gross, Christian H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC400558/
https://ncbi.nlm.nih.gov/pubmed/15105144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004
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