Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase

Topoisomerase IV and DNA gyrase are related bacterial type II topoisomerases that utilize the free energy from ATP hydrolysis to catalyze topological changes in the bacterial genome. The essential function of DNA gyrase is the introduction of negative DNA supercoils into the genome, whereas the esse...

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Autors principals: Bellon, Steven, Parsons, Jonathan D., Wei, Yunyi, Hayakawa, Koto, Swenson, Lora L., Charifson, Paul S., Lippke, Judith A., Aldape, Robert, Gross, Christian H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC400558/
https://ncbi.nlm.nih.gov/pubmed/15105144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004
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