Crystal Structures of Escherichia coli Topoisomerase IV ParE Subunit (24 and 43 Kilodaltons): a Single Residue Dictates Differences in Novobiocin Potency against Topoisomerase IV and DNA Gyrase

Topoisomerase IV and DNA gyrase are related bacterial type II topoisomerases that utilize the free energy from ATP hydrolysis to catalyze topological changes in the bacterial genome. The essential function of DNA gyrase is the introduction of negative DNA supercoils into the genome, whereas the esse...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bellon, Steven, Parsons, Jonathan D., Wei, Yunyi, Hayakawa, Koto, Swenson, Lora L., Charifson, Paul S., Lippke, Judith A., Aldape, Robert, Gross, Christian H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2004
विषय:
Mechanisms of Action: Physiological Effects
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC400558/
https://ncbi.nlm.nih.gov/pubmed/15105144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004
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