Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV

[Image: see text] Benzimidazole 1 is the lead compound resulting from an antibacterial program targeting dual inhibitors of bacterial DNA gyrase and topoisomerase IV. With the goal of improving key drug-like properties, namely, the solubility and the formulability of 1, an effort to identify prodrug...

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Publicado en:ACS Med Chem Lett
Main Authors: O’Dowd, Hardwin, Shannon, Dean E., Chandupatla, Kishan R., Dixit, Vaishali, Engtrakul, Juntyma J., Ye, Zhengqi, Jones, Steven M., O’Brien, Colleen F., Nicolau, David P., Tessier, Pamela R., Crandon, Jared L., Song, Bin, Macikenas, Dainius, Hanzelka, Brian L., Le Tiran, Arnaud, Bennani, Youssef L., Charifson, Paul S., Grillot, Anne-Laure
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499827/
https://ncbi.nlm.nih.gov/pubmed/26191374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00196
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