Hepatitis C Viral Evolution in Genotype 1 Treatment-Naïve and Treatment-Experienced Patients Receiving Telaprevir-Based Therapy in Clinical Trials

BACKGROUND: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone. However, genotypic changes could be observed in TVR-treated patients w...

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Main Authors: Kieffer, Tara L., De Meyer, Sandra, Bartels, Doug J., Sullivan, James C., Zhang, Eileen Z., Tigges, Ann, Dierynck, Inge, Spanks, Joan, Dorrian, Jennifer, Jiang, Min, Adiwijaya, Bambang, Ghys, Anne, Beumont, Maria, Kauffman, Robert S., Adda, Nathalie, Jacobson, Ira M., Sherman, Kenneth E., Zeuzem, Stefan, Kwong, Ann D., Picchio, Gaston
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325239/
https://ncbi.nlm.nih.gov/pubmed/22511937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034372
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