Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

BACKGROUND: Development of compensatory mutations within the HIV p7/p1 and p1/p6 protease cleavage site region has been observed in HIV-infected patients treated with protease inhibitors. Mechanisms of fitness compensation may occur in HCV populations upon treatment of HCV protease inhibitors as wel...

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Autors principals: Sullivan, James C, Zhang, Eileen Z, Bartels, Doug J, Tigges, Ann, Dorrian, Jennifer L, Kwong, Ann D, Kieffer, Tara L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499439/
https://ncbi.nlm.nih.gov/pubmed/22866919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-147
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