Characterization of V36C, a Novel Amino Acid Substitution Conferring Hepatitis C Virus (HCV) Resistance to Telaprevir, a Potent Peptidomimetic Inhibitor of HCV Protease

We characterized a novel substitution conferring moderate resistance to telaprevir, a peptidomimetic inhibitor of hepatitis C virus protease. V36C conferred a 4.0-fold increase in the telaprevir 50% inhibitory concentration in an enzyme assay and a 9.5-fold increase in the replicon model. The replic...

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Main Authors: Barbotte, Laetitia, Ahmed-Belkacem, Abdelhakim, Chevaliez, Stéphane, Soulier, Alexandre, Hézode, Christophe, Wajcman, Henri, Bartels, Doug J., Zhou, Yi, Ardzinski, Andrzej, Mani, Nagraj, Rao, B. Govinda, George, Shelley, Kwong, Ann, Pawlotsky, Jean-Michel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876365/
https://ncbi.nlm.nih.gov/pubmed/20368394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01796-09
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