Restoration of the Activated Rig-I Pathway in Hepatitis C Virus (HCV) Replicon Cells by HCV Protease, Polymerase, and NS5A Inhibitors In Vitro at Clinically Relevant Concentrations

Development of persistent hepatitis C virus (HCV) infection may be mediated by HCV NS3 · 4A protease-dependent inhibition of host innate immunity. When double-stranded RNA (dsRNA) is detected in virus-infected cells, host innate immunity mounts an antiviral response by upregulating production of typ...

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Detalhes bibliográficos
Main Authors: Kalkeri, Gururaj, Lin, Chao, Gopilan, Jenna, Sloan, Kevin, Rijnbrand, Rene, Kwong, Ann D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754339/
https://ncbi.nlm.nih.gov/pubmed/23836176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00399-13
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