Relative Replication Capacity and Selective Advantage Profiles of Protease Inhibitor-Resistant Hepatitis C Virus (HCV) NS3 Protease Mutants in the HCV Genotype 1b Replicon System

We characterized the selective advantage profiles of a panel of hepatitis C virus (HCV) NS3 protease mutants with three HCV protease inhibitors (PIs), BILN-2061, ITMN-191, and VX-950, using a genotype 1b HCV replicon system. Selective advantage curves were generated by a novel mathematical method th...

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Detalhes bibliográficos
Main Authors: He, Yupeng, King, Martin S., Kempf, Dale J., Lu, Liangjun, Lim, Hock Ben, Krishnan, Preethi, Kati, Warren, Middleton, Timothy, Molla, Akhteruzzaman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258550/
https://ncbi.nlm.nih.gov/pubmed/18086851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01149-07
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