In Vitro and In Vivo Antiviral Activity and Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor ABT-450

The development of direct-acting antiviral agents is a promising therapeutic advance in the treatment of hepatitis C virus (HCV) infection. However, rapid emergence of drug resistance can limit efficacy and lead to cross-resistance among members of the same drug class. ABT-450 is an efficacious inhi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pilot-Matias, Tami, Tripathi, Rakesh, Cohen, Daniel, Gaultier, Isabelle, Dekhtyar, Tatyana, Lu, Liangjun, Reisch, Thomas, Irvin, Michelle, Hopkins, Todd, Pithawalla, Ron, Middleton, Timothy, Ng, Teresa, McDaniel, Keith, Or, Yat Sun, Menon, Rajeev, Kempf, Dale, Molla, Akhteruzzaman, Collins, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335891/
https://ncbi.nlm.nih.gov/pubmed/25451053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04227-14
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