In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir

Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6 in vitro (half-maximal [50%] inhibitory concentration = 3.5 to 11.3 nM) and the repl...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Ng, Teresa I., Tripathi, Rakesh, Reisch, Thomas, Lu, Liangjun, Middleton, Timothy, Hopkins, Todd A., Pithawalla, Ron, Irvin, Michelle, Dekhtyar, Tatyana, Krishnan, Preethi, Schnell, Gretja, Beyer, Jill, McDaniel, Keith F., Ma, Jun, Wang, Guoqiang, Jiang, Li-Juan, Or, Yat Sun, Kempf, Dale, Pilot-Matias, Tami, Collins, Christine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740381/
https://ncbi.nlm.nih.gov/pubmed/29084747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01620-17
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