In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir

Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6 in vitro (half-maximal [50%] inhibitory concentration = 3.5 to 11.3 nM) and the repl...

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Publicado no:Antimicrob Agents Chemother
Main Authors: Ng, Teresa I., Tripathi, Rakesh, Reisch, Thomas, Lu, Liangjun, Middleton, Timothy, Hopkins, Todd A., Pithawalla, Ron, Irvin, Michelle, Dekhtyar, Tatyana, Krishnan, Preethi, Schnell, Gretja, Beyer, Jill, McDaniel, Keith F., Ma, Jun, Wang, Guoqiang, Jiang, Li-Juan, Or, Yat Sun, Kempf, Dale, Pilot-Matias, Tami, Collins, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740381/
https://ncbi.nlm.nih.gov/pubmed/29084747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01620-17
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