In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir

Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with 50% effective concentration (EC(50)) values ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Pibrentasvir demonstrated similar activity against a panel of chimeric r...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Ng, Teresa I., Krishnan, Preethi, Pilot-Matias, Tami, Kati, Warren, Schnell, Gretja, Beyer, Jill, Reisch, Thomas, Lu, Liangjun, Dekhtyar, Tatyana, Irvin, Michelle, Tripathi, Rakesh, Maring, Clarence, Randolph, John T., Wagner, Rolf, Collins, Christine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404558/
https://ncbi.nlm.nih.gov/pubmed/28193664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02558-16
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