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Evolution of Resistant M414T Mutants among Hepatitis C Virus Replicon Cells Treated with Polymerase Inhibitor A-782759

Treatment of hepatitis C virus (HCV) replicon cells with any single specific anti-HCV inhibitor in vitro leads to a rapid selection of resistant mutants. However, the source and the kinetic evolution of these resistant mutants during treatment are poorly understood. In this study we developed allele...

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Detalhes bibliográficos
Main Authors: Lu, Liangjun, Mo, Hongmei, Pilot-Matias, Tami J., Molla, Akhteruzzaman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891376/
https://ncbi.nlm.nih.gov/pubmed/17371824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01004-06
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