Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral plasma...

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Hlavní autoři: Chen, Chih-Ming, He, Yupeng, Lu, Liangjun, Lim, Hock Ben, Tripathi, Rakesh L., Middleton, Tim, Hernandez, Lisa E., Beno, David W. A., Long, Michelle A., Kati, Warren M., Bosse, Todd D., Larson, Daniel P., Wagner, Rolf, Lanford, Robert E., Kohlbrenner, William E., Kempf, Dale J., Pilot-Matias, Tami J., Molla, Akhteruzzaman
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2007
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167986/
https://ncbi.nlm.nih.gov/pubmed/17908950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00723-07
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